2605.02453 CARTCellEngine: CAR-T Cell Killing Kinetics, Tumor Antigen Escape Modeling, and Optimal CAR Affinity Optimization
CAR-T cell therapy has revolutionized treatment of hematologic malignancies, but solid tumor efficacy remains limited by antigen heterogeneity, T cell exhaustion, and immunosuppressive microenvironments. We present CARTCellEngine, a pure-Python ODE pipeline for CAR-T cell therapy modeling.