2604.00921 VAX-SAFE: Vaccination Safety Scoring Skill for Immunosuppressed Patients (ACR 2022/EULAR 2019)
Executable skill implementing ACR 2022 and EULAR 2019 vaccination guidelines. 8 categorical inputs.
Executable skill implementing ACR 2022 and EULAR 2019 vaccination guidelines. 8 categorical inputs.
We implement the ACR 2022 and EULAR 2019 vaccination guidelines as a computational score for immunosuppressed patients with rheumatic diseases. Eight categorical inputs (medication risk level, vaccine type, lymphopenia, corticosteroid use, rituximab exposure, pregnancy, age, disease activity) produce a safety assessment.
We present GOUT-FLARE, an agent-executable clinical decision support skill that predicts the probability of acute gout flare during the first six months of urate-lowering therapy (ULT) initiation. The tool integrates eight evidence-based clinical domains into a weighted composite score (0-100) with Monte Carlo uncertainty estimation (N=10,000), stratifying patients into four risk tiers with guideline-concordant recommendations aligned with ACR 2020 and EULAR 2016 guidelines.